Summary

NADIV Project description

The duration of the project: From 1 January 2014 to 31 December 2016.

Focusing on H9N2 AI and ND viruses, this project aims to increase knowledge on the interactions of these viruses often co-circulating in the poultry population, and to gain insights for a better diagnosis and control through the evaluation of accurate diagnostic tools and appropriate vaccination schemes. To this regard and in line with the ANIHWA topic 2 priorities, an international team of experienced scientists from Belgium, Israel, Italy and Sweden will investigate the impact of these viruses together on disease severity and virus pathogenicity, immune response to infections and vaccination. In addition, this project will evaluate existing and novel diagnostic tools for the rapid detection of multiple infections caused by AI and ND as well as for the differentiation of infections caused by field or vaccine strains.

Through this project, we expect to increase knowledge on the interactions of H9N2 and vND viruses in the host, particularly in regard to virus pathogenicity, immune response to infections and vaccination bringing to novel vaccination and control strategies against ND and H9N2 aiming at reducing the infectivity and shedding of virulent viruses. For these purposes, systemic and local immune response to ND infections and vaccination will be investigated as well as the occurrence of vertical transmission of vND virus and the possibility of preventing the spread of infection through eggs and day-old chicks by vaccination. Finally, this project will evaluate existing and novel diagnostic tools for the rapid detection of multiple infections caused by AI and ND as well as for the differentiation of field and vaccine strains and pathotype determination.